Speaking on the Today Show about the reports, the 76-year-old was adamant there could only ever be one man who could play the archaeologist and that man was him.
"Nobody is gonna be Indiana Jones," he said.
"Don't you get it? I'm Indiana Jones. When I'm gone, he's gone. It's easy."
And then, he seemingly got Chris Pratt mixed up with Chris Pine - we've all done it, mate - adding: "This is a hell of a way to tell Chris Pine this. I'm sorry, man." I'm sure he'll get over it...
Harrison Ford has played the role of Indiana Jones since 1981. Credit: Paramount Pictures
Ford has played Indiana since 1981 when he starred in Raiders of the Lost Ark, he then starred in three sequels - Indiana Jones and the Temple of Doom in 1984, The Last Crusade in 1989 and Kingdom of the Crystal Skull in 2008.
He's previously ruled out handing over his iconic fedora to his Kingdom of the Crystal Skull co-star Shia LaBeouf (who played his son Mutt Williams).
Talking to ScreenRant about the hat, he said: "What are you talking about? It's mine. I would love to do another Indiana Jones movie.
"George Lucas is working on an idea now. Shia can get his own hat. I earned that hat."
Ford isn't showing any signs of slowing down, either and will be back in 2021 for a fifth movie.
Speaking about making a new movie, he said: "I'd love to do another Indiana Jones. You know, an audience being there that has enjoyed the films, a character that has a history and a potential, kind of a rollicking good movie ride for the audience, Steven Spielberg as a director - what's not to like?"
Indy's iconic fedora on display at the Prop Store film memorabilia exhibition. Credit: PA
The new flick doesn't have a title yet, but is tipped to be released in July 2021, but what we do know is that as well as Spielberg and Ford, George Lucas will also be involved, with Spielberg said he would 'never make an Indiana Jones film without him'.
Disney CEO Bob Iger has also hinted that the franchise won't end with number five, either, explaining that the new movie 'won't just be a one-off'.
Featured Image Credit: PA