The kangaroo found viral fame after shots of his muscular physique were shared online back in 2015.
Roger was rescued while still a tiny baby by Chris Barnes, who owns the sanctuary. Chris shared the sad news about Roger's death in a post on Facebook.
He wrote: "It's a very sad day here today for we have lost our beautiful boy, Roger.
"Ten years ago, I built this sanctuary to house Roger and a couple of his wives, Ella (and) Abigail.
"We built it so they'd have a place to live.
"Roger was our alpha male for many years and he grew up to be a kangaroo that people from all over the world have grown to love as much as we love him too."
A video of the kangaroo shared alongside a post announcing his death has been shared over 1,300 times and has been flooded with comments from people paying tribute to the red kangaroo, with one dubbing him the 'Schwarzenegger of roos'.
Roger went viral after photos of him were shared online. Credit: Facebook/Kangaroo Sanctuary Alice Springs
The kangaroo's mind-boggling muscular body saw him hit headlines a few years back, and he didn't just look like a tough guy, according to Chris he wasn't to be messed with.
He told the Daily Mail Australia: "His daily exercise regime is sparring [kickboxing] his rivals and chasing his human 'Mum', me.
"He also loves crushing metal buckets.
"Don't mess with a 'Big Red', they'll disembowel you... or worse."
Roger the kangaroo has died aged 12. Credit: Facebook/Kangaroo Sanctuary Alice Springs
In 2016, Chris revealed that Roger was living with arthritis as he hit his advancing years. In a short video which showed Roger bent over, Chris said: "I would never have been able to pat Roger like I am now, but he is getting old."
Roger was a tiny orphaned Joey when he was found by Chris back in 2006. He was rescued from the road-side where he sat next to his dead mother and was nursed by Chris and his team on the sanctuary. He went on to become the sanctuary's alpha male - clearly.
Featured Image Credit: Facebook/Kangaroo Sanctuary Alice Springs