In the most brutal part of the post, the former boxer says: "You're always talking about somebody is broke, but the last time I checked it was Curtis Jackson that filed for bankruptcy not Floyd Mayweather.
"So quick to gossip like a Bitch, why don't you tell everybody how you got Herpes from DJ. Where's your memes for that, huh? Or better yet, post on how your Coca-Cola deal wasn't really 300 million you fucking liar and tell how that spinning G-Unit necklace that somebody got robbed for was fake.
"Just remember, I was with you everyday and your driver Bruce was my driver also. I know where all your bones are buried, so be easy Curtis Jackson! And by the way, don't ask to borrow no more money from me." Wow, bet he wasn't seeing that coming.
The post has whipped social media up into a frenzy.
And in another twist, 50 Cent has responded - it was only a matter of time really, wasn't it?
He made a joke at Mayweather's spelling and grammar (mature).
In another post the rapper said: "This bum b!tch want in, champ making up shit. When I return the favor he won't recover because I'm gonna tell you the truth."