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The Breaking Bad star posted a video on Instagram, wearing a mask as he told followers that he had Covid-19 'a little while ago'.
"Very lucky, very mild symptoms," he said.
Cranston explained how he was left wondering what he could do to help, so he popped down to the UCLA Blood and Platelet Center to donate some of his plasma with Covid-19 antibodies.
"Hopefully the plasma donation can help some other people," he added.
Cranston ended up donating around 840ml of the 'liquid gold' in total, and was even able to watch an old movie in the process.
The actor also went into more detail about his experience with the virus in the video's caption, saying his symptoms had only been mild.
He wrote: "About now you're probably feeling a little tied down, restricting your mobility and like me, you're tired of this!! Well, I just want to encourage you to have a little more patience.
"I was pretty strict in adhering to the protocols and still... I contracted the virus. Yep. it sounds daunting now that over 150,000 Americans are dead because of it.
"I was one of the lucky ones. Mild symptoms."
Cranston also asked others to continue following measures to help stop the virus from spreading, including face masks - which he said he'd be doing.
He added: "I count my blessings and urge you to keep wearing the damn mask, keep washing your hands, and stay socially distant.
"We can prevail - but ONLY if we follow the rules together. Be well - Stay well."
Hanks appeared on NPR's Wait Wait... Don't Tell Me!, where he revealed that he and Rita had both taken antibody tests, which confirmed they have had the virus and do in fact have antibodies in their blood.
He explained: "We have not only been approached; we have said, 'Do you want our blood? Can we give plasma?' And, in fact, we will be giving it now to the places that hope to work on what I would like to call the Hank-ccine."