The 44-year-old rapper - who is legally known as Ye - has removed everything from the page but has not deactivated or deleted it completely.
It's not clear why Ye has removed everything from his account but it's something he has done in previous years, even going further and deactivating his pages.
Over the weekend, the father-of-four shared a Thanksgiving post where he took the time to thank his family, fans and even the haters.
There are also suggestions that he's wiped everything from his account following the death of his close friend and fashion designer Virgil Abloh.
According to Complex, his latest Sunday Service performance was dedicated to Virgil and came just hours after his death was announced by family.
Just days ago, he posted a picture of him and wife Kim Kardashian sharing a kiss, despite Kim filing for divorce.
Also speaking at the Angeles Mission's Annual Thanksgiving event, Kanye said: "The narrative God wants is to see that we can be redeemed in all these relationships.
"We've made mistakes. I've made mistakes. I've publicly done things that were not acceptable as a husband.
"I'm not letting E! write the narrative of my family. I'm not letting Hulu write the narrative of my family. I am the priest of my home."
He went on to say: "If the enemy can separate Kimye, there's going to be millions of families that feel like that separation is ok.
"But when God brings Kimye together, there's going to be millions of families that are going to be influenced to see that they can overcome the work of the separation, of trauma the devil has used to capitalize to keep people in misery while people step over homeless people to go to the Gucci store."
It seems Thanksgiving took its toll on the musician as fans believed it was the first since separating from Kim.
He spoke of his desire to be with his family when he explained: "I'm trying to express this way in the most sane way possible, the most calm way possible, but I need to be back at home."
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