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During their long-running feud, 84-year-old Takei suggested that Shatner was 'not the fittest specimen' and said he was a 'guinea pig'.
When asked what he made of Shatner becoming the oldest person to go into space by Page Six, Takei responded: "He's boldly going where other people have gone before.
"He's a guinea pig, 90 years old and it's important to find out what happens."
He added: "So 90 years old is going to show a great deal more on the wear and tear on the human body, so he'll be a good specimen to study.
"Although he's not the fittest specimen of 90 years old, so he'll be a specimen that's unfit."
Replying to his old colleague, 90-year-old Shatner wrote: "Don't hate George. The only time he gets press is when he talks bad about me.
Don't hate George. The only time he gets press is when he talks bad about me. He claims 50+ years ago I took away a camera angle that denied him 30 more seconds of prime time TV. ♂️ I'm giving it back to him now by letting him spew his hatred for the world to see! Bill the :pig:
- William Shatner (@WilliamShatner) October 16, 2021
"He claims 50+ years ago I took away a camera angle that denied him 30 more seconds of prime time TV.
"I'm giving it back to him now by letting him spew his hatred for the world to see!"
Shatner has also responded to Prince William after it emerged that the royal believed people could be working on 'trying to repair this planet, not trying to find the next place to go and live'.
To this, Shatner defended the historic flight, saying he's got the 'wrong idea', explaining that the space mission was a 'baby step' to getting 'polluting industries... off of Earth'.
Interviewed by Entertainment Tonight, the actor said about the duke: "He's a lovely Englishman. He's going to be king of England one day. He's a lovely, gentle, educated man, but he's got the wrong idea.
"The idea here is not to go, 'Yeah, look at me. I'm in space.'
"No, I would tell the prince, and I hope the prince gets this message, this is a baby step of getting industry, all those polluting industries... off of Earth."