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It appears the would-be thieves targeted the 55-year-old rapper's home after discovering he had been taken ill and was at the hospital receiving treatment.
The home, in the Brentwood area of Los Angeles, was apparently picked out by a burglary ring who made an attempt to get into the property at around 10pm on Tuesday night.
However, the Los Angeles Police Department said nothing was taken, according to ABC7.
The police said the suspects are known to bang on the fences and doors of properties before breaking and entering.
Officers originally believed the suspected burglars could be targeting the house of US Vice President Elect Kamala Harris, who also lives in the area.
However, after a short investigation they have determined the suspects were trying to get into the house that Dre - real name Andre Young - owns.
While on a surveillance operation, the LAPD officers saw an SUV in the area that was believed to have been involved.
After a short chase, the suspects were apprehended, and four people have now been taken into custody in Pacific Palisades.
The officers also discovered a backpack full of tools that could be useful in a burglary, including saws and crowbars.
While Dre has yet to comment on the suspected burglary attempt, he has released a statement on his social media thanking fans for their support after he was taken ill, as well as updating them on his condition.
The West Coast music mogul confirmed that he is 'doing great and getting excellent care' at the Cedars-Sinai Medical Center.
He also said he expects he will be released from the medical facility before too long.
Dre wrote: "Thanks to my family, friends and fans for their interest and well wishes. I'm doing great and getting excellent care from my medical team.
"I will be out of the hospital and back home soon. Shout out to all the great medical professionals at Cedars. One Love!!"
After his illness emerged, support messages for the rapper came in from the music world and beyond.
Former NWA bandmate Ice Cube wrote: "Send your love and prayers to the homie Dr. Dre."
Snoop Dogg said: "GET WELL DR DRE WE NEED U CUZ."
Missy Elliott tweeted: "Prayers up for Dr. Dre and his family for healing & Strength over his mind & body."