Lionsgate has announced that Black will be voicing the sarcastic yellow robot, in turn reuniting the actor with director Eli Roth and former co-star Cate Blanchett - both of whom he worked with on 2018 fantasy film The House with a Clock in Its Walls
In a statement, Roth said: "I am so excited to reunite with Jack, this time in the recording booth.
"Claptrap is the funniest character in the game, and Jack is perfect to bring him to the big screen."
Black and Blanchett are also set to star alongside Kevin Hart and Jamie Lee Curtis, with two-time Emmy-winning screenwriter Craig Mazin (Chernobyl) behind the latest draft of the screenplay.
The movie is based on the video game series of the same name, created by Gearbox Software and published by 2K Games for multiple platforms.
Set in a space-western sci-fi world, the action role-playing first-person-shooter games have become one of the best-selling video game franchise of all time.
The Wrap reports that the games have sold 66 million units sold-in worldwide, including more than 24 million units of Borderlands 2, which is the 'highest selling title in the history of 2K'.
The most recent instalment, Borderlands 3, was launched in September 2019 and has since sold more than 11 million units worldwide - also winning the Best Multiplayer Game award at Gamescom 2019 and Best Ongoing Game at Gamescom 2020.
According to Deadline, the forthcoming movie will be set in the distant future, where four 'vault hunters' travel to the distant planet Pandora to hunt down an alien vault rumoured to contain advanced technology.
Nathan Kahane, president of the Lionsgate Motion Picture Group, said: "We couldn't have been more in sync with our filmmakers and casting executives as we approached this role.
"It's one of the biggest no-brainer casting decisions we've ever made. Everyone who's ever played the game knows Jack is perfect for this part. We're thrilled he will add his endless comic energy and voice to our film - he'll bring so much to the movie."
Avi Arad and Ari Arad are producing through their Arad Productions banner alongside Erik Feig of Picturestart.
Executive producers, meanwhile, are Randy Pitchford - EP of the Borderlands video game franchise and founder of Gearbox Entertainment - and Strauss Zelnick, chairman and CEO of 2K parent Take-Two Interactive.