Grimes has revealed she was hospitalised after her appearance on Saturday Night Live last week (8 May), in an edition hosted by her partner Elon Musk.
The 33-year-old appeared on the US TV show alongside fellow pop star Miley Cyrus.
But it turns out Grimes - real name Claire Elise Bouche - suffered a panic attack following the show, and she was taken to hospital for treatment.
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She shared the news on Instagram with her 1.9 million followers, posting two photos of herself and Miley in their costumes.
Grimes wrote: "Forgot to post these cuz I somehow caused myself to have a panic attack and went to the hospital yesterday which tbh was quite scary and I suppose it's a good time to start therapy.
"But nonetheless - wowwwww @mileycyrus is good live and so chill!
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"So grateful to the SNL team for being so kind and letting me sneak in as princess peach and so proud of my beautiful E (which I know will upset the grimes fans so I apologize in advance) but he killed it."
Grimes appeared as Princess Peach in a Super Mario Bros-inspired sketch during her SNL appearance.
Hosting the show, her 49-year-old partner Musk revealed that he has Asperger's syndrome in his opening monologue.
He said that he was 'making history' as the first person with Asperger's to host the show.
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The Tesla CEO and SpaceX founder began: "It's an honour to be hosting Saturday Night Live - I mean that. Sometimes after I say something, I have to say 'I mean that' so people really know that I mean it.
"That's because I don't always have a lot of intonational variation in how I speak - which I'm told makes for great comedy.
"I'm actually making history tonight as the first person with Asperger's to host SNL."
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As the audience applauded, Musk added with a smile: "Or at least the first person to admit it."
He continued to joke that this meant he wouldn't 'make a lot of eye contact' with the cast, but was alright at 'running human in emulation mode'.
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Later on in his speech he said: "Look, I know I sometimes say or post strange things, but that's just how my brain works.
"To anyone I've offended, I just want to say I reinvented electric cars, and I'm sending people to Mars in a rocket ship. Did you think I was also going to be a chill, normal dude?"
Featured Image Credit: Instagram/GrimesTopics: Saturday Night Live