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While both Wilder and Fury gave the fight everything they had, in the end the Gypsy King proved too strong for Wilder and the bout was stopped in the 11th round.
That means the undefeated Fury has now won two of the three fights between the two heavyweights, with the first fight resulting in a split-decision draw.
Wilder was taken to hospital as a precaution immediately after the fight, and has now given his initial thoughts on what must be a painful loss, given the acrimonious build-up to the fight.
According to Boxing Scene, Wilder said: "I did my best, but it wasn't good enough.
"I'm not sure what happened. I know that in training he did certain things, and I also knew that he didn't come in at 277 to be a ballet dancer.
"He came to lean on me, try to rough me up and he succeeded."
Both boxers had moments during which the fight could have swung in their favour, with Wilder successfully knocking Fury down twice in the fourth round, the first time Fury has been felled twice within the same round.
Fury had already sent Wilder sprawling to the canvas in the previous round, and managed to get himself back up and secured the stoppage in the penultimate round.
Eventually, the boxing brain of Fury won the day, and while Wilder can no doubt take pride in his performance, and having been part of one of the great heavyweight fights, he refused to turn their bitter rivalry around post-fight.
Fury has since described Wilder as a 'sore loser' and said that his opponent refused to shake hands or show mutual respect after their shared ordeal.
The Morecambe-based WBC champion said: "I said, 'Well done.' And he said, 'I don't wanna show any sportsmanship or respect.' I said, 'No problem.'
"I was very surprised by that but he's a sore loser, an idiot.
"To be a top fighting man, you've got to show guts and respect and he couldn't do it tonight. And that's it.
"He couldn't do it so I'll pray for him. I'm just thankful we all got out the fight in one piece and go home to our lovely families."
Now, Fury could look to a unification bout against Oleksandr Usyk, or wait until the result of a rematch between Usyk and Anthony Joshua.
Dillian Whyte may also represent an alternative opponent for Fury, should those fights not materialise.
What comes next for Wilder is less clear.
Featured Image Credit: Alamy
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