Bill, 65, kicks off his video showing a map of the US, which is coloured red in the places where people have been wearing masks.
He overlays this with a second map, this time with black ink to show where the most coronavirus cases are occurring.
He explains: "Here's a map of the United States. The red ink shows where people are wearing masks.
"The black ink shows where people are getting sick with coronavirus.
"I hope you can see, the fewer the masks, the more the sick."
He then enlists the help of a colander to explain the next part, pushing a small red dot on a stick through one of the holes, while telling his followers: "There's a perception that the virus can travel through the fibres of a mask, like this red dot."
He then explains how the virus actually travels.
"Viruses don't travel by themselves," he said.
"No, they travel in little droplets of spit and snot. And the fibres [of the mask] are a tangle.
"So when the droplet gets into the fibres of the mask, it gets trapped. This is not that hard to understand, everybody. That's why we have rules about wearing a mask."
He demonstrates this with a little ball which he then tries to drop down a board full of pegs - as he does so, all the balls are stopped before they reach the bottom.
He then breaks down the concept of 'rules', for those who really seem to struggle with following them.
"Now, you know about rules," he says. "You pay taxes on the whole road, but you only get to drive on one side at a time. Otherwise..."
At this point he makes two toy cars smash into each other.
He finishes the clip by slipping on his own mask and saying: "So everyone please wear a mask, thank you... oh, you can hear me fine, right through the mask."
Since posting the clip four days ago, it's been viewed almost four million times and has attracted thousands of comments from people thanking Bill for his no-nonsense explainer.
One wrote: "I think Bill Nye needs to be shown to anti-maskers."
Another person joked: "Bill Nye single handedly ended Covid."
A third wrote: "The King said it, y'all better listen now."