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Takei and Shatner have been at it for years, with their disagreement starting on the set of Star Trek where Takei says his co-star would ignore him, and even asked for a rewrite of one of the films to change Takei's role.
These are two old men, with Takei aged 84 and Shatner 90, but there's definitely life in the old lads yet, and they certainly know how to cast some shade.
Takei suggested that Shatner was 'not the fittest specimen' and said that he was a 'guinea pig'.
The man has just become the oldest person to ever go into space, but go off George!
"We are just at the beginning, but how miraculous the beginning is." @WilliamShatner is ready to go to space. #NS18 pic.twitter.com/u3MnOAbWtW
- Blue Origin (@blueorigin) October 12, 2021
When asked what he made of the whole thing by Page Six, Takei responded: "He's boldly going where other people have gone before,
"He's a guinea pig, 90 years old and it's important to find out what happens."
Speaking at the opening of the show Thoughts of a Colored Man, Takei continued: "So, 90 years old is going to show a great deal more on the wear and tear on the human body, so he'll be a good specimen to study.
"Although he's not the fittest specimen of 90 years old, so he'll be a specimen that's unfit!"
Tell us what you really think, eh?
Anyway, Shatner seemed to enjoy himself, and his incredible - albeit brief - journey to the stars.
He had a great time floating around and experiencing weightlessness, and he even had time to share some of his thoughts with the people watching around the world.
Speaking afterwards, the Canadian said: "I hope I never recover from this,
"I'm so filled with emotion about what just happened. It's extraordinary, extraordinary.
"It's so much larger than me and life.
"It hasn't got anything to do with the little green men and the blue orb. It has to do with the enormity and the quickness and the suddenness of life and death.
"To see the blue colour whip by you, and now you're staring into blackness... everybody in the world needs to do this.
"Everybody in the world needs to see this."
In less grand terms, he's also addressed his feud with Takei.
Once upon a time, he said: "There's a psychosis there... There must be something else inside George that is festering, and it makes him unhappy that he takes it out on me...
"Why would he go out of his way to denigrate me? It's sad, I feel nothing but pity for him."