Known by pretty much everyone for guest starring as Rachel Green's sister in Friends, Christina Applegate is a cherished household face and name.
So, it's no surprise that everyone was on their feet as she appeared in front of hundreds at the 75th Emmy Awards.
The award-winning actress, known in recent years for her brilliant role in Netflix's Dead To Me opposite Linda Cardellini, had everyone on their feet after speaking candidly about her health problems.
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Applegate took to the stage alongside host Anthony Anderson to present the first award of the night, for the category of Best Supporting Actress in a Comedy.
The gong went to Ayo Edebiri for her role in The Bear, but the star of the segment was Christina herself.
She appeared with a cane, some two years after first being diagnosed with multiple sclerosis (MS).
The entire audience took to their feet, with 52-year-old Applegate even cracking a joke about them making fun of her MS by so easily getting our of their seats.
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She also quipped: "We don't have to applaud every time I do something."
The moment reduced the Hollywood star to tears.
In 2021, Applegate revealed her MS diagnosis on X, formerly known as Twitter.
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She said: “It's been a strange journey. But I have been so supported by people that I know who also have this condition."
According to the NHS, MS is a condition that can affect the brain and spinal cord, causing a wide range of potential symptoms.
This includes problems with vision, arm or leg movement, sensation or balance.
Sadly, it is a lifelong condition and cannot be cured. For some, it causes serious disability.
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The NHS says: "It's most commonly diagnosed in people in their 20s, 30s and 40s although it can develop at any age.
"It's about two to three times more common in women than men.
"MS is one of the most common causes of disability in younger adults."
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Main symptoms include:
- fatigue
- difficulty walking
- vision problems, such as blurred vision
- problems controlling the bladder
- numbness or tingling in different parts of the body
- muscle stiffness and spasms
- problems with balance and co-ordination
- problems with thinking, learning and planning
Topics: Celebrity, TV and Film, NHS, Health, US News