The couple have opened up about their decision to step back from the Royal Family, with Meghan claiming there were times she 'didn't want to be alive anymore'.
Meanwhile, Harry revealed that his dad Prince Charles stopped taking his calls after he announced plans to distance himself from his duties in the Royal Family.
Piers was predictably unimpressed by what he saw, however, and offered a damning verdict on Good Morning Britain.
The host said: "I'm angry to the point of boiling over today, I'm sickened by what I've just had to watch.
"This is a two-hour trashathon of our Royal Family, of the monarchy, of everything the Queen has worked so hard for, and it's all being done as Prince Philip lies in hospital. They trash everybody."
Piers also took umbrage with Meghan claiming there had been 'concerns and conversations' among the Royals about their son Archie, with an unnamed member of the family making an issue of 'how dark his skin [was] going to be'.
The GMB host continued: "They basically make out the entire Royal Family are a bunch of white supremacists, by dropping this race bombshell... They didn't name which one it was, they just throw it out there, so it could be any member of the Royal Family.
"And Harry says, 'I'll never say who it was.' Well, you better say it fast."
'I'm sickened by what I've had to watch.'
'It's a 2 hour trash-athon of everything the Queen has worked so hard for, while her husband is in hospital.'@piersmorgan starts the show with his reaction to the Harry and Meghan interview.
Tune in tonight @itv at 9pm. pic.twitter.com/AIXKvXtIoq
- Good Morning Britain (@GMB) March 8, 2021
It's a lovely bit of promo from Piers, with the interview due to air on ITV tonight (Monday 8 March) at 9pm.
In the interview, Meghan said she had suicidal thoughts but was denied support.
She said: "I just didn't see a solution.
"Look, I was really ashamed to have to say [she had experienced suicidal thoughts] at the time and ashamed to have to admit it to Harry especially, but I knew that if I didn't say that, I would do it.
"I just didn't want to be alive anymore. It takes so much courage to admit you need help, to admit how dark of a place you're in."
She continued: "I went to one of the most senior people to get help. I share this because there are so many people who are afraid to voice that they need help, and I know personally how hard it is to not just voice it, but when you voice it... [to hear someone say] no.
Revealing she even spoke to the palace's HR team, she recalled: "I remember this conversation like it was yesterday. They said, 'My heart goes out to you because I can see how bad it is, but there's nothing we can do for you because you're not a paid member of the institution.'
"[Going to a hospital] is what I was asking to do. You can't just do that, I couldn't call an Uber to the palace, you couldn't just go. You have to understand... that was the last time I saw my passport, my driver's license, my keys. All that gets turned over."
Piers said he didn't believe Meghan's claims though - which co-host Susanna Reid described as a 'pathetic reaction'.
Piers said: "Who did you go to? What did they say to you? I'm sorry, I don't believe a word she said, Meghan Markle. I wouldn't believe it if she read me the weather report.
"The fact that she's fired up this onslaught against our Royal Family, I think is contemptible."
You can watch the full interview with Meghan and Harry on ITV at 9pm tonight (8 March) and on the ITV Hub once the programme has been broadcast.
Featured Image Credit: ITV