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Doctor Who Provided New Cancer Drug Explains Why She Thinks It Worked

Home> News

Published 15:49 7 Jun 2022 GMT+1

Doctor Who Provided New Cancer Drug Explains Why She Thinks It Worked

The breakthrough study saw tumours vanish in 100 percent of participants

Emily Brown

Emily Brown

Oncologist Dr. Andrea Cercek, who was involved in a new trial which saw cancerous tumours 'vanish' in patients, has offered her thoughts on why the drug worked.

The breakthrough trial was detailed in a paper published in the New England Journal of Medicine on Sunday (5 June) and involved 18 participants who had been diagnosed with rectal cancer.

The patients were treated with an immunotherapy drug called dostarlimab, and following the trial the doctors found the rectal cancer had vanished in all 18 patients, so much so that it could not be detected by physical exam, endoscopy, PET scans or MRI scans.

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Dr. Andrea Cercek, an oncologist at Memorial Sloan Kettering Cancer Center and a co-author of the paper, discussed the results with CNN after the study was published and admitted the doctors 'didn't expect it'.

"We'd certainly never seen this before, it's really what cancer doctors' dreams are made of," she continued.

Dr. Cercek explained dostarlimab works by 'unlocking the body's natural immune system to fight cancer', and said this particular treatment works in 'specific cancer cells' which lack a gene which enables them to repair their DNA, ultimately leading to mutations.

She said: "When we give immunotherapy like dostarlimab it really just revs up the immune system so that it sees the cancer and gets rid of it. But what's so remarkable here is that it completely eliminated the cancer, the tumours just vanished."

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The doctor went on to explain that such results are typically only visible in 10 percent of patients with advanced cancer, making the study's results even more 'striking'.

Tumours were undetected in physical exams, MRIs and PET scans.
Alamy

Dr. Luis A. Diaz Jr., another author of the paper, told The New York Times he believes 'this is the first time this has happened in the history of cancer'.

The inspiration for the study came from a clinical trial led by Dr. Diaz in 2017, which involved 86 people diagnosed with metastatic cancer which shared a gene mutation that prevented cells from repairing damage to DNA.

Patients from the earlier trial took a checkpoint inhibitor for up to two years, after which results revealed tumours shrank or stabilised in about one third to half of the patients and disappeared altogether in 10 percent of the participants.

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The results led Dr. Cercek and Dr. Diaz to question what would happen if the drug were administered earlier in the course of the disease, resulting in the more recent successful trial.

Featured Image Credit: TikTok/@cnn/Alamy

Topics: Health, US News, Cancer, Science

Emily Brown
Emily Brown

Emily Brown is the Community Desk Lead at LADbible Group. Emily first began delivering news when she was just 11 years old - with a paper route. She went on to graduate with a BA Hons in English Language in the Media from Lancaster University before contributing to The Sunday Times Travel Magazine and Student Problems. She joined UNILAD in 2018 to cover breaking news, trending stories and longer form features, and now works as Community Desk Lead to commission and write human interest stories from across the globe.

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