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All travellers wishing to take the trips must prove that they've had two doses of one of the approved vaccines at least seven days before they board the vessels.
This follows fellow cruise companies Virgin Voyages and Saga Cruises, who have introduced similar rules recently.
P&O, which is part of the Carnival Group, is planning to run two trips this year around the British Isles.
Their ship Britannia will sail from Southampton along the south coast of Britain for three or four days, whereas new ship Iona will head from Southampton to the island it is named after for seven days.
As well as proving that they've been fully vaccinated, passengers must also have travel insurance that includes 'medical and repatriation cover' as well as expenses that relate to Covid-19.
The crew of the ship, as well as the guests, will be expected to observe social distancing and wear masks where appropriate.
Anyone who test positive for the virus whilst on board will be placed into isolation and made to quarantine.
The President of P&O Cruises, Paul Ludlow, said: "This is moving at pace.
"We anticipate by the 27 June, which is our first sailing, there will be a government-accredited scheme to prove your vaccination, but at the very least, then of course, a letter from your GP would suffice."
He added: "At the moment we're stipulating that all guests of all ages must be vaccinated to come on board with us,"
In their vaccine policy statement, the company wrote: "Given the advanced progress of the UK vaccination programme and strong expressed preference on the part of our guests for this limited series of UK coastal cruises, these sailings on Britannia and Iona will be for UK resident, Covid-19 vaccinated guests only.
"For these cruises the definition of 'vaccinated' is a minimum of seven days following the second dose of the currently approved Covid-19 vaccines being administered.
"Proof of vaccination and the dates given will be required (approved forms of evidence will be confirmed closer to time of departure) and this will be required to be shown at the terminal prior to boarding.
"Failure to provide this evidence will result in denial of boarding. There is no age restriction on this series of UK coastal cruises but all guests of all ages must meet the requirements of the Covid-19 vaccination policy."
They added: "All other P&O Cruises holidays currently on sale do not require guests to be vaccinated."
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