The former porn star turned sports commentator announced the news to her followers on Instagram last night.
Sharing a snap of herself tucking into some sushi, with her laptop open to her OnlyFans page in the background, Mia wrote: "I have a full time job... as an accountant."
The account will be posting 'SWF [suitable for work] content, kinda' according to a description from Mia.
Posting on her account, which costs $11.99 (£9.28) per month, Mia thanked fans for their support, writing: "THANK YOU SO F***ING MUCH for supporting me on this new and exciting platform.
"I am finally growing into my self-confidence in who I am and the decisions I make for me, and this is my way of being myself outside the perimeters of conventional social media.
"Even though I will not be creating nude content, I am going to be treating this page like my Instagram without terms of service lol.
"I want to take my power back and just post what I want and what makes me feel good, and I'm just so thankful that y'all are along for this wild ride.
"This is all very new to me, I've never been on a platform as fan-facing, so any suggestions for improving my presence here is greatly appreciated! I love you!"
In a follow-up post she once again thanked her fans for their 'kind words' and for making her feel welcome on the site, before saying she was 'excited' for the future.
Earlier this year, Mia said the porn videos she made when she was 21 will 'haunt her' for the rest of her life as she urged other women to think twice before going into the industry.
Posting on Instagram, she wrote: "Those 11 videos will haunt me until I die, and I don't want another girl to go through that - because no one should.
"Long story short: don't do porn. And if you do, don't do it with a company. Do it for yourself, on your own terms.
"And if you consume porn, make sure it's ethical and not from giant corporations who profit off exploiting women. Like your groceries, shop local and direct from the creators."Featured Image Credit: Instagram/Mia Khalifa