His character recently joined the Marvel Cinematic Universe, and fans would love to see him and Spidey together in a movie.
The good news is that Reynolds would love to see it too. The bad news is that it isn't his decision to make.
Asked about the possibility of seeing DP alongside Tom Holland's Spider-Man, the 44-year-old told LADbible: "I think that's like one of those sort of, you know, vision board matchups that would be amazing.
"But the Spider-Man rights are not exclusively MCU or Marvel, they're also Sony. It's a whole business thing that would have to happen. So I have no idea.
"I mean, I personally would love to see Deadpool with Spider-Man at some point, but I would have to be a little above my pay grade to make that decision."
That's right - there are people above Ryan Reynolds' pay grade.
Hopefully Reynolds and Marvel fans will get their wish one day, but in the meantime, we can all entertain ourselves with Free Guy, which is out on Friday (13 August).
The feel-good flick sees Reynolds star alongside Jodie Comer (Killing Eve) and Joe Keery (Stranger Things), and it's just the tonic we need right now.
The premise is that Reynolds' character Guy is a non-playable character in a game, but due to his super advanced coding, he becomes self-aware and falls for gamer Millie (Comer). They then become embroiled in a battle - fought on Earth and the virtual world - to save the game from its greedy developer (Taika Waititi), who plans to shut it down.
Think The Truman Show meets Elf, chock-a-block with laughs, CGI and heartfelt moments.
The movie marks Comer's first starring role in a major movie, and her co-stars have heaped praise on her.
Reynolds said: "I learned a lot from her - and I've done I think about eight million more movies than she has.
"She's just so gifted and so nimble, and such a quick study.
"I mean, I know it was her first film - and we all know how talented she is from Killing Eve - but to see her just, on the first day of work, step on that stage like she's been there for 1,000 years, was the mark of somebody who's going to be around a long, long time.
"She's really exceptional, and it doesn't hurt that she's a very, very nice person."
Check out these photos from the #FreeGuy London premiere! Get your tickets today and see #FreeGuy in theaters this Friday. https://t.co/1988qhApwb pic.twitter.com/8oTDULAzjA
- Free Guy (@FreeGuyMovie) August 9, 2021
Keery agreed that working with the 28-year-old was an education.
He told LADbible: "She's such a strong actress, and she can kind of just tackle anything that's thrown her way - and makes it look quite easy.
"So I feel like I learned a lot from her and had a lot of fun actually doing the scenes. And then, you know, to top it all off, she's just a really kind of down to earth and normal person."
No doubt we'll be seeing a lot more of the Liverpudlian on the big screen.