The Met Office has warned that tiles could be ripped off roofs and there could be a possible 'danger to life' ahead of the weekend.
According to the weather body, Scotland and Wales, as well as the North West, North East and Yorkshire are set to be among the worst affected areas.
Northern Ireland is also predicted to be hit by the strong winds, with a yellow weather warning put in place from Wednesday (5 October).
In a statement, the Met Office said: "There is a chance of a deep low pressure system bringing gusts of 70 to 80 mph to northern parts of the UK on Wednesday.
"Should this develop disruption would be expected. However, the most likely scenario is for gusts of 55 to 65 mph within parts of the warning area, most likely the northern Irish Sea and parts of eastern Scotland, bringing some more localised impacts.
"In addition, heavy rain may prove an additional hazard across northwestern areas."
Brits have also been warned that strong gusts could cause flying debris and tiles to fall from roofs, while travel is expected to be affected.
Explaining the warning, the Met Office says: "There is a small chance of injuries and danger to life from flying debris.
"There is a slight chance of some damage to buildings, such as tiles blown from roofs.
"There is a small chance of longer journey times or cancellations as road, rail, air and ferry services are affected.
"There is a small chance that some roads and bridges could close.
"There is a slight chance that power cuts may occur, with the potential to affect other services, such as mobile phone coverage."
A separate yellow warning has also been issued for parts of Scotland for tomorrow (4 October).
The Met says some areas could suffer flooding, while heavy rain is expected.
It says: "Rain will turn heavy and persistent across western Scotland during the early hours of Tuesday, clearing southeast during the morning.
"Widely 30 to 50 mm of rainfall is likely with perhaps 80 mm over some of the mountains."
It adds: "Bus and train services probably affected with journey times taking longer
"Spray and flooding on roads probably making journey times longer."
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