Biden is to have the procedure performed as part of a routine annual health check, and Harris will hold the fort until he is back in action.
Harris will be acting president while the 79-year-old goes under anaesthetic on Friday morning.
White House press secretary Jen Psaki said in a statement: "As was the case when President George W. Bush had the same procedure in 2002 and 2007, and following the process set out in the Constitution, President Biden will transfer power to the Vice President for the brief period of time when he is under anaesthesia.
"The Vice President will work from her office in the West Wing during this time."
Former President George W. Bush did indeed transfer power briefly over to his vice president Dick Cheney when he was under for a colonoscopy, and did so again a few years later in 2007 for the same reason.
A colonoscopy is a procedure that checks for abnormalities in the large intestine and rectum, and involves insertion of a camera into the anus, which is then observed to check for abnormalities.
Biopsies can also be performed whilst the procedure is taking place.
At the age of 79, Biden is already the oldest person to ever hold the office of President of the United States of America.
Amongst the population of the USA, there have been some concerns about his health during his time in office, and he hurt himself in 2020, breaking his foot whilst playing with his dog Major.
Luckily, that injury healed properly, with Dr Kevin O'Connor from the Delaware Orthopaedic Specialists telling the press that his foot was 'completely healed'.
"This injury has healed as expected, and he will return to his usual exercise regimen," said the doctor, who has been Biden's primary care doctor since 2009 and works for The George Washington Medical Faculty Associates.
He added that the president's 'symptoms have improved as expected, and he is adhering to a strict physical therapy regimen."
"As we explained initially, sprains of the foot can sometimes be a more significant injury than the bony fractures which accompany them.
"This x-ray is to check to assure that he has achieved good ligamentous stability,"