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Having announced last year that he was retiring from performing as his health continued to worsen, the 76-year-old has also now explained how Parkinson's has started affecting his home life.
In an interview with the Observer, the legendary stand-up said he sleeps like a 'wild animal' because of the disease, and that such disturbed sleeping has forced him out of the bed he shared with Pamela, his wife of 30 years.
He said: "I sleep like a wild animal.
"Laughing and singing or having fights. Pamela has to sleep in another bed."
But while 'The Big Yin' worries he's being a pain, he admitted Pamela still comes in to plump-up his pillows each night - which is undeniably adorable.
"So far, she has never tutted," he said.
"And she's a rather attractive nurse."
The Glaswegian also said his wife helps him if he can't get out of bed in the mornings, saying 'little changes' have quickly become normal.
Raising his arms in the air and smiling, he said: "I can't get out of bed, so I put my hands up like this when I want to get up and Pam pulls me to the side of the bed. I can't get my legs over."
Connolly, who now lives in Florida with Pamela, first made his name after appearing on the BBC's chat show Parkinson in 1975, shortly after transitioning from folk singer to fully-fledged comedian.
He went on to become one of the UK's best-loved entertainers, appearing in a raft of TV series and films on both sides of the Atlantic, including Indecent Proposal, Muppet Treasure Island and The Hobbit: The Battle of the Five Armies.
Now, however, the pace has had to slow down as he settles in to retired life.
But Connolly has said he's not scared by the changes his Parkinson's has brought on, explaining in 2018 documentary Billy Connolly: Made in Scotland: "As bits slip off and leave me, talents leave and attributes leave.
"I don't have the balance I used to have, I don't have the energy I used to have. I can't hear the way I used to hear, I can't see as good as I used to. I can't remember the way I used to remember. And they all came one at a time and they just slipped away.
"It is like somebody is in charge of you and they are saying, 'Right, I added all these bits when you were a youth, now it is time to subtract'."
He added: "I'm a damn sight nearer the end than I am the beginning. But it doesn't frighten me, it's an adventure."
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