Christina Applegate was left hospitalised and 'screaming' with pain over new illness not related to MS diagnosis

Christina Applegate recently opened up about the painful time she was having with a new illness that left her hospitalised on top of her regular struggles with MS.

The actor has been very candid about the autoimmune disease she was diagnosed with back in 2021, as the Married... With Children star said that she 'doesn't leave the house anymore' due to her multiple sclerosis.

It's a progressive disease where the body's immune system attacks the protective covering around the brain and spinal cord. There is no cure as treatments only slow down the symptoms for a while.

She said her first warning sign was that her 'toes weren't feeling right' and a friend encouraged her to go and see a doctor.

Now, on her MeSsy podcast she's spoken about a new illness which left her in a great deal of pain.

She was left in terrible pain and went right to hospital (Kevin Winter/Getty Images)

Speaking with her friend and podcast co-host Jamie-Lynn Sigler, Applegate explained that she started feeling unwell while she was in Europe visiting family members.

During her flight back to the US, she decided she would go straight to hospital upon her return as she would prefer not to be in a position where she had to rush there at some inconvenient hour.

She said: "I'm like, I wanna be admitted. I'm staying here because I want answers.

"I want every test that you can possibly think of or ones that you haven't even thought of, and I want them done."

Applegate woke up the following day with a terrible pain in her side which was 'radiating' from her back to her front, leading her to think 'my appendix is bursting'.

Applegate said the pain was so bad she thought her appendix was going to burst, but it was a kidney infection (Gilbert Flores/Variety via Getty Images)

The star admitted that initially docs questioned whether the culprit could be a urinary tract infection and even went as far as questioning her wiping techniques.

“Like, what am I back-wiping? Like, seriously, I'm 53,” she said.

The actor explained she was in 'so much pain' that she was 'screaming' and was sent for an emergency CT scan at 2.00am, which showed she was suffering from a kidney infection.

It had started in the right kidney but since moved to the left one as well, and told her podcasting pal: "Because of this kidney infection, I have to have intravenous antibiotics right now. And that's where we're at."

Her representatives told People that she had since returned home from the hospital after her treatment for a kidney infection, with a statement saying she had been there for seven days.

In the past, Applegate said her MS meant it was 'never a good day' but there were some things she was looking forward to and hoped to tick off the bucket list.

Her two big goals are to 'work with Shirley MacLaine' and to 'do shots with Cher', while she's also developed a passion for the TV show Love Island.