Arrests made in connection with Matthew Perry's death last year

There have been multiple arrests made in connection to Matthew Perry's death, according to TMZ.

The Friends star was found dead in a hot tub at his Los Angeles home on 28 October last year.

Perry's death was initially reported as accidental with the autopsy revealed a cause of the combined effects of ketamine use and drowning.

However, it was more recently confirmed by the Los Angeles Police Department (LAPD) and the Drug Enforcement Administration (DEA) that there would be a criminal investigation into the 54-year-old actor's death.

Law enforcement sources reportedly told TMZ that search warrants had been executed with computes, phones and other electronic equipment seized to determine who supplied the star with the ketamine that led to his death.

Matthew Perry died in October last year. (David M. Benett/Dave Benett/Getty Images)

It is said at least one doctor has been arrested, along with a number of dealers who helped to arrange and deliver the drugs to Perry.

This is as it is alleged the ketamine the star ingested was not legally prescribed and though he had been receiving ketamine infusion therapy for anxiety and depression, his last session was a week and a half before his death.

And the contents from the infusion would have only been in the Chandler Bing actor's system for three to four hours.

Reportedly, the criminal investigation found text messages leading to these arrests.

During his life, Perry was very open about his struggles with addiction over the years, discussing much of it in his autobiography.

The actor had been a staunch advocate who warned of the dangers of alcohol and drugs, after experiencing substance abuse issues since the young age of 14.

Perry was very open about his addiction struggles. (Charles Sykes/Bravo/NBCU Photo Bank/NBCUniversal via Getty Images)

According to the autopsy, Perry had been sober for 19 months at the time of his death, with no known substance abuse relapses since then. It's also reported investigators found no alcohol, illicit drugs or drug paraphernalia at the scene.

The actor's tragic passing last year was confirmed in a statement by NBC, the studio behind Friends, which said: “We are incredibly saddened by the too soon passing of Matthew Perry.

"He brought so much joy to hundreds of millions of people around the world with his pitch-perfect comedic timing and wry wit. His legacy will live on through countless generations."

His co-stars also released a heartbreaking statement which included: "We are all so utterly devastated by the loss of Matthew. We were more than just cast mates. We are a family.

“There is so much to say, but right now we’re going to take a moment to grieve and process this unfathomable loss."

LADbible has contacted the LAPD and Perry's former representatives for comment.