Matthew Perry's tragic final words revealed during investigation into actor's death

An investigation into the death of actor and author Matthew Perry has revealed the final words he spoke to his assistant before he died.

Five people have been charged in connection with Perry's death, which occurred last year when the actor was 54.

They include Perry's live-in assistant, two doctors and a woman referred to as the 'ketamine queen', with US attorney Martin Estrada saying that the investigation unearthed a 'broad underground criminal network' of people who took advantage of the actor.

At a recent press briefing in Los Angeles it was announced that Perry became addicted to intravenous ketamine while seeking treatment for depression and anxiety, resulting in him becoming involved with 'unscrupulous doctors who saw Perry as a way to make quick money'.

Perry had been receiving ketamine infusion therapy as a treatment for depression and anxiety, but his last official treatment had been more than a week prior to his death.

Matthew Perry died last year, five people have been charged in connection with his death. (Phillip Faraone/Getty Images for GQ)

The indictment claims that doctors Salvador Plasencia, 42, and Mark Chavez, 54, discussed supplying Perry with ketamine, writing 'I wonder how much this moron will pay' in messages.

Plasencia allegedly taught Perry's assistant, who had never received medical training, how to apply the intravenous ketamine.

Jasveen Sangha, 41, a woman known as the 'ketamine queen' also supplied ketamine to Perry through a 'broker' called Eric Fleming, 54, who pleaded guilty to one count of conspiracy to distribute ketamine and one count of distribution of ketamine resulting in death.

Court documents show that Fleming admitted to distributing the ketamine which took Matthew Perry's life, and that it had been supplied by Sangha.

Iwasama, 59, pleaded guilty to a charge conspiring to distribute ketamine causing death, admitting he had been 'repeatedly injecting Perry with ketamine without medical training'.

Perry's final words to his assistant were 'shoot me up with a big one'. (Axelle/Bauer-Griffin/FilmMagic)

The actor's assistant said he performed multiple injections on 28 October, 2023, the day Perry died.

According to court documents, Perry asked Iwasama to give him a dose of ketamine at 8.30am on 28 October, and then asked for a second dose around four hours later.

He then asked for a third dose of ketamine to be administered later in the day, with documents indicating that his final words to Iwasama were 'shoot me up with a big one'.

The assistant then left Perry's home to run errands and when he returned he found the actor dead.

Plasencia pleaded not guilty to conspiracy to distribute ketamine, seven counts of distribution of ketamine and two charges related to allegations he falsified documents during the investigation into Perry’s death.

Sangha pleaded not guilty to conspiracy to distribute ketamine, maintaining a drug-involved premises, possession with intent to distribute methamphetamine, possession with intent to distribute ketamine and five counts of distribution of ketamine.