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The actor - whose ex-husband Johnny Depp recently lost a 'wife beater' libel case regarding their relationship - asked people if they were 'done ignoring' claims of abuse.
In a tweet sharing a New Yorker article about the allegations against Manson, the 34-year-old said: "...... and yet, no one sees the trend here? Everyone wants to tag a Bathroom wall, no one wants to understand the writing.
"Evan & I aren't the 1st to raise our hands. Are you done ignoring it?"
...... and yet, no one sees the trend here? Everyone wants to tag a Bathroom wall, no one wants to understand the writing. Evan & I aren't the 1st to raise our hands. Are you done ignoring it? The Marilyn Manson Reckoning ' The New Yorker https://t.co/NboMFBHV0t
- Amber Heard (@realamberheard) February 4, 2021
Manson's former fiancée, actor Evan Rachel Wood, had previously stated she is a survivor of rape and domestic abuse - and on Monday (1 February), she claimed her abuser was Manson. Manson denies the allegations.
Wood, 33, said the singer - whose biggest hit single was a cover of Soft Cell's 'Tainted Love' - was a 'dangerous man'.
She said: "He started grooming me when I was a teenager and horrifically abused me for years. I was brainwashed and manipulated into submission.
"I am done living in fear of retaliation, slander, or blackmail. I am here to expose this dangerous man and call out the many industries that have enabled him, before he ruins any more lives.
"I stand with the many victims who will no longer be silent."
Several other women subsequently accused the 52-year-old singer - real name Brian Warner - of abusing them, and he issued a statement denying the allegations.
In a post on Instagram, he said: "Obviously, my art and my life have long been magnets for controversy, but these recent claims about me are horrible distortions of reality.
"My intimate relationships have always been entirely consensual with like-minded partners. Regardless of how - and why - others are now choosing to misrepresent the past, that is the truth."
Manson's former employee Ashley Walters claims he 'frequently became violent' when she was working as his personal assistant, and he would offer her up for sexual encounters with collaborators.
Model Sarah McNeilly said Manson used to lock her in bedrooms and threaten to 'bash my face in with a baseball bat'.
Manson's label, Loma Vista Records, has now severed ties with the singer.
In a statement to The Hollywood Reporter, the record label said: "In light of today's disturbing allegations by Evan Rachel Wood and other women naming Marilyn Manson as their abuser, Loma Vista will cease to further promote his current album, effective immediately.
"Due to these concerning developments, we have also decided not to work with Marilyn Manson on any future projects."