Amy Schumer opened up about the 'red flags' she noticed while using Ozempic which indicated that the drug really didn't agree with her.
The comedian, 43, previously revealed that she was left 'bedridden' after taking the diabetes drug, which also promotes weight loss, a few years ago.
Although she lost around '30 pounds', she was struck down by a host of unfortunate side effects which forced her to stop taking it.
Ozempic isn't a case of one size fits all, as the medication can cause a number of gastrointestinal issues for some users, such as nausea, vomiting, diarrhea, and constipation.
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And in hindsight, Schumer said there were several indicators that it was not a good fit for her.
Take a look at this:
Speaking on The Howard Stern Show in January this year, the Trainwreck star explained: "I have this gene, GDF15, which makes you extremely prone to nausea, which is why I was so sick during my pregnancy.
"I tried Ozempic almost three years ago and I was like, bedridden. I was like, vomiting - and then you have no energy. But other people take it and they’re all good."
She and Stern then began to reel off a list of potential side effects, which Schumer described as 'red flags'.
The stand-up star continued: "You’re like, ‘Wait a minute. Can we slow down?’ The side effects are you have a better personality.
"I tried it and I was vomiting and I’m in bed and my son’s like, ‘Can you play tag?’ I’m like, 'I can’t.' I was shrivelling. I couldn’t lift my head off the pillow, so what’s the point?”
Schumer has since revealed that she has switched to another weight-loss drug, Mounjaro, which has been tonnes better for her.
In a video shared to Instagram this weekend, the Kinda Pregnant actress reminisced about her semaglutide days while telling fans: "Three years ago, I tried Wegovy.
"I was puking, I couldn’t handle it," she explained. "I don’t know if they’ve changed the formula, whatever."
Schumer went on to say that she'd had a health referral via online midlife health clinic Midi Health, before discovering she 'was in perimenopause'.
The mother-of-one, who shares son Gene with husband Chris Fischer, said she has started taking estrogen and progesterone which have helped manage her perimenopause symptoms.
Schumer then added: "My hair is fuller, my skin is better, I have more energy, I want to get down more...if you know what I mean. I’m talking about sex. So that’s been great and Mounjaro’s been great.
"And, look, it’s not covered by insurance unless you have diabetes or like severe obesity, which most of the internet thinks I have.
"But I’m having a really good experience with it and I wanted to keep it real with you about that."
Schumer has been candid about her health with her supporters in the past, previously revealing that she was diagnosed with Cushing's Syndrome after being trolled online.
She later said that the jabs about her 'puffier face' from social media users had done her a favour, as she 'wouldn't have known' about the condition 'if the internet hadn't come for her so hard'.
Schumer isn't the only star to open up about their journey with weight loss drugs, as Sharon Osbourne revealed she 'didn't want to' be as thin as she ended up after taking it.
Like the comedian, the former X Factor judge complained that she had encountered some side effects, saying: "You don’t throw up physically, but you have that feeling.
"It was about two to three weeks where I felt nauseous the whole time. You get very thirsty, and you don’t eat."
Ozempic suppresses a person's appetite by mimicking the hormone glucagon-like peptide-1 (GLP-1) that is released after eating, making people feel full and resulting in them eating less.
Common side effects of the weight loss jab include nausea and diarrhoea, but studies indicate potential side-effects are 'mild' and 'subside with time'.