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Practitioner warns Omeprazole users can face 'two problems' after using drug
Home>Lifestyle
Updated 17:25 10 Jun 2026 GMT+1Published 15:38 10 Jun 2026 GMT+1

Practitioner warns Omeprazole users can face 'two problems' after using drug

An estimated 35 million Omeprazole prescriptions were handed out in England between 2022 and 2023

Anish Vij

Anish Vij

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Natural remedy expert Simon Mills has revealed two problems with using one of the most prescribed drugs in England.

Around 73 million proton pump inhibitor (PPIs) prescriptions were handed out in England from 2022 to 2023, including 35 million Omeprazole prescriptions.

PPIs are a type of medicine that reduces the amount of acid your stomach makes, with Omeprazole being one of the most commonly used types in Britain.

For most patients, the NHS says Omeprazole should only be used for short-term use for relief from indigestion, heartburn or acid reflux symptoms.

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“What Omeprazole does is shut down the acid production in the stomach. So you don't get as much damage from reflux,” Mills told the Diary of a CEO podcast.

(Getty Stock Images)
(Getty Stock Images)

"When we're getting acid reflux, actually, it's not because you got too much acid. It's because you're refluxing it. It's going back up into the oesophagus. But Omeprazole will put an end to that."

The 'two problems' with taking Omeprazole

“There are two problems with that. First is that the list of problems occurring from long-term Omeprazole use is beginning to grow and is serious... All sorts of things are beginning to be downstream problems associated with long-term Omeprazole use,” Mills explained.

The second issue is that ‘once you're on it, it's really difficult to come off it, and you get a famous rebound effect’.

(YouTube/The Diary Of A CEO)
(YouTube/The Diary Of A CEO)

“So you come off Omeprazole, and wow, you get much more trouble. So the only thing to do is take more Omeprazole, and people find it really hard to come off it,” he added.

“So you have to do a lot of hard work to wean people off and do it in sorts of different ways.”

As for the NHS’ guidance, they say: “Research has found that some people who have been taking PPIs for more than two months find that their body is producing more acid (referred to as rebound acid) to compensate for the acid-reducing effects of these medications.

“This can mean that your symptoms can worsen again when trying to stop taking the PPI medication. If this happens to you, it should only be for up to two weeks after stopping the PPI.”

Five long-term side effects of taking Omeprazole

(Getty Stock Images)
(Getty Stock Images)

According to the NHS, long-term use can lead to:

• An increased risk of developing a gut infection (Clostridium difficile) that causes severe diarrhoea

• An increased risk of broken bones or fractures

• An increased risk of pneumonia

• A drop in magnesium levels, which can cause tiredness, muscle weakness, dizziness, and abnormal heart rhythms

• A delay in diagnosing gastric and stomach cancers

Three ways to get off Omeprazole

The NHS says your GP will usually provide a few different ways to stop your PPI intake:

• Quit cold turkey or when your course has finished

• Only take it when 'you have rebound acid symptoms'

• Reduce dose gradually

Featured Image Credit: Getty Stock Images

Topics: Lifestyle

Anish Vij
Anish Vij

Anish is a Journalist at LADbible Group and is a GG2 Young Journalist of the Year 2025. He has a Master's degree in Multimedia Journalism and a Bachelor's degree in International Business Management. Apart from that, his life revolves around the ‘Four F’s’ - family, friends, football and food. Email: [email protected]

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@Anish_Vij

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